Nano-biohybrid actuator

Biohybrid actuators by integrating live biological elements hold promise to develop the next generation of stimuli-responsive, energy-efficient, automated robots capable of navigating complex surroundings and performing a number of otherwise formidable tasks. Instead of humans and other living things, biohybrid robots can be used in various fields such as drug screening and toxicity assessment. Recently, we have developed a biohybrid robot composed of HA-AuNP-embedded muscle bundles to augment the actuation and monitor positive and negative inotropic effects.

Organoid based biohybrid robot

The nano-biohybrid actuator with enhanced driving force can implement efficient movement, but there is no system for controlling it. Our group is developing a biohybrid robot in which a nano-biohybrid actuator was efficiently combined with motor neuron spheroids, various brain organoids, and retinal organoids to induce movement of the bio-hybrid actuator in response to external stimuli. Research is also being conducted on a development of biohybrid robot composed of biohybrid robot on the nanopattern electrode. Biohybrid robot is an excellent tool to study signal transduction between living tissues in that they enable analysis of the effects of tissue-specific diseases and drugs on other tissues. Nanopattern electrodes are an efficient way to measure biological signals generated by biohybrid robot. In conclusion, the biohybrid robot is a cutting-edge system that incorporates human movement and signal transduction in vitro.